Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life
نویسندگان
چکیده
منابع مشابه
Zinc biochemistry: from a single zinc enzyme to a key element of life.
The nutritional essentiality of zinc for the growth of living organisms had been recognized long before zinc biochemistry began with the discovery of zinc in carbonic anhydrase in 1939. Painstaking analytical work then demonstrated the presence of zinc as a catalytic and structural cofactor in a few hundred enzymes. In the 1980s, the field again gained momentum with the new principle of "zinc f...
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Renal aminoacylase is inactivated by dialysis against metal complexing agents such as o-phenanthroline. Activity can be restored by addition of zinc ions. A zinc dissociation constant of about 10(-10)M at pH 7.8 is obtained by titration of the enzyme with a metal ion buffer. The reactivity of the SH groups of the enzyme is considerably affected by zinc ions. The enzyme contains two essential zi...
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ژورنال
عنوان ژورنال: Advances in Nutrition
سال: 2013
ISSN: 2156-5376,2161-8313
DOI: 10.3945/an.112.003038